This research outlines a method to quantify precipitant yield formed in droplets through chemical reaction in picolitre volumes, and outlines a potential route to studying nucleation of CaCO3 relevant to the atmosphere [1, 2]. Calcium carbonate (CaCO3) aerosol particles are formed in a droplet as inclusions through ion exchange reaction in optical tweezers. Aqueous calcium chloride (CaCl2) and sodium carbonate (Na2CO3) droplets coalesce to form a CaCO3 precipitant that is quantified and characterised using whispering gallery modes that arise in Raman spectra.