Hygroscopic properties of inhalable pharmaceutical aerosols optically trapped within a model lung

N. Davidsona, H. -J. Tongb, M. Kalberer, P. C. Sevilled, A. Warde, M. Kuimovaf and F. D. Popea.

Solid particles injected directly from four different pressurised metered dose inhalers were stably captured in an optical trap and examined online via Raman spectroscopy. Micron-sized particles of inhalable drugs were captured and analysed at a range of relative humidity (RH) conditions. One drug found to be hygroscopic was also analysed at temperatures closer to the inside of the human body. This technique represents a viable method for testing the suitability of specific particle size ranges of inhalable drugs with hygroscopic properties.

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