Asthma is highly prevalent and associated with high morbidity and mortality. It affects 30-50 million people in Europe, often starting in infancy and persisting throughout the lifetime. Asthma is a major global health challenge with growing impact, affecting more than 300 million people worldwide and at least 10% of all Europeans. People with both severe and mild asthma live at risk of life-threatening asthma attacks, leading to at least 500,000 hospitalisations each year. Approximately 5-10% of asthma cases are so severe that current treatments do not work. 3 people die of asthma every day in the UK.