Microdosing and Feeding of Inhalation Powders via a Vibratory Sieve-Chute System

Eva Faulhammer, M. O. Besenhard, M. Llusa, S. Biserni, V. Calzolari, A. Ferrari, A. Paudel, J.G. Khinast

This study describes a powder dosing system with a vibratory sieve mounted on a chute that doses particles into a capsule. Vertical vibration occurred within a broad range of frequencies and amplitudes. During dosing events, the fill weight was accurately recorded via a capacitance scale, making it possible to analyze filling characteristics, i.e., the fill rates and their robustness. The results show that fill rate robustness varied distinctly in the operating space. The performed micro dosing studies exhibit that fill rate robustness is of upmost importance to achieve accurate (micro) dosing. Prior to every dosing study, the operating space, i.e., settings that yield a steady flow of powder into the chute, was determined for three inhalation carriers. The performed low-dose studies with the original Microdose system show that capsules can be filled with doses in the range of 2.5mg and a fill weight variability below 5% in less than one second. If dosing time is not an issue, the proposed system can dose with almost any accuracy, limited only by the accuracy of the dynamic scale. It could be demonstrated that such a vibratory sieve chute system is also suitable for continuous (micro-) feeding applications and therefore, MG2’s Microdose was rebuild for microfeeding studies. Initial results reveal that robust feeding rates of less than 5 mg/h are feasible.

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