Investigation into the in vitro Performance of Anti-static vhcs by Particle Size Distribution using the next Generation Pharmaceutical Impactor (ngi)

Scott Courtney, Benjamin Pratt

Aerodynamic particle size distribution and total delivered dose (TDD) performance testing of several Anti-static Valved Holding Chambers (VHCs) has been conducted with a series of selected pMDI drugs using the Next Generation Impactor (NGI) at a flow rate of 30 L/min. The main body of the Antistatic VHCs tested is made from three distinctively different types of materials of construction – including aluminium (VORTEX Non Electrostatic Holding Chamber), Acrylonitrile Butadiene Styrene , ABS (OptiChamber Diamond Anti-static chamber) and a Polypropylene Blend Polymer (Medical Developments Internationals Anti-static Compact Space Chamber Plus & AeroChamber Plus Flow-Vu Anti-static VHC). Results have shown that the VHCs made from the polypropylene blend polymer outperform the other VHCs tested for overall TDD and FPD/EFPD deliveries over all drugs tested, with total performance ranking over all three platforms being AS-CSCP > ACP-FV > VOR-NE > OCD-AS.

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