To enable the delivery of high concentrations of aerosolized therapeutic agents at high payloads from viscous solutions or sols, aerosols were generated from surfactant and polyvinylpyrrolidone, PVP with SUPRAER®. These fluids were atomized and the water evaporated using warm dilution air and infrared radiation. The resultant dry aerosol was concentrated using a virtual impactor. The masses of aerosol collected on filters at the output were determined gravimetrically. Particle size distributions were measured with a Marple-Miller cascade impactor. Viscosities were measured with a capillary rheometer. Surface tensions were measured with a contact angle analyzer. Aerosols between 2.6 and 4 μm MMAD were generated from 10% PVP solutions and 9.33% surfactant suspensions (34 cP) at aerosolization rates between 0.5 and 3 ml/minute with a modest increase in particle size with aerosolization rate that was less evident when surfactant was aerosolized. Particle size increased with viscosity over the range of 4 to 39 cSt. When aerosolizing 10% 8 kDa PVP solutions, the output increased in proportion to the aerosolization rate with 193 mg/min being delivered at 64% efficiency. Outputs of 0.7 and 1.2 g were collected in 3.3 and 6.7 min, respectively. When 9.33% surfactant suspensions were aerosolized, up to163 mg/min was delivered at 59% efficiency. The surface tension of surfactant was not changed following aerosolization and resuspension. SUPRAER increases the viscosity range over which respirable aerosols can be generated at up to 3 mg/s opening up possibilities for new treatments for respiratory ailments with surfactant and large molecules.