A detailed understanding of physicochemical properties of pharmaceutical containing aerosol can be used to improve targeted drug delivery in the lung

A.E. Haddrell, J.F. Davies, L.A. Dailey, D. Murnane, J.P. Reid

Summary

The efficacy of a pharmaceutical is dependent on the location in the body in which the majority of the dose is delivered.  In the case of drug delivery to the lung (DDL) specifically, the region in the lung where the dose is delivered will have a direct effect on the magnitude of the biological response.  In this study, we explore the potential that the region in lung where the majority of the dose is delivered can be manipulated through understanding and controlling the hygroscopic behaviour of the aerosolized pharmaceutical.  A suite of novel single aerosol analysis techniques are used to probe the physicochemical properties of aerosol particles generated from formulation mimics of commercially available pharmaceutical products.  Additionally, the effect of putting additives into the starting formulations on the hygroscopic behaviour of the aerosol is studied.  The information gained from these experiments can then be input into a whole lung model to estimate total and regional dose.  This model is based on the standard International Commission on Radiological Protection model (ICRP) wherein the detailed aerosol dynamic hygroscopic behaviour prior to and during inhalation is added.  The results from this study demonstrate that manipulating either the starting formulation or the treatment of the aerosol prior to inhalation, or both, have a significant effect on where the majority of the dose is delivered.

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