Deposition in three nasal cast models with a new concept of nasal administration (Retronose) vs nasal spray
Laurent Vecellio1,2, Deborah Le Pennec1, Guillaume Grevin2 & Alain Regard2
1 CEPR, INSERM U1100, University of Tours, Tours, France
2Nemera, La Verpilliere, France
Nasal drug delivery is a non-invasive method that allows a rapid and high local therapeutic effect. Deposition in the different target region of the nasal cavity is an important key factor for improving the drug efficacy. A new concept of nasal administration (Retronose) has been compared to a nasal spray pump on three different nasal cast models. Nasal casts were heated and humidified during nasal drug administration. A nasal pump (Flixonase®, France, GSK) was used for nasal drug administration to the nose. The Retronose prototype uses a pMDI to administer the drug through the buccal cavity model during the nasal expiratory phase. Drug deposition in the different anatomical regions was measured by spectrophotometry and scintigraphy measurements. Results show a more homogenous deposition in terms radioactivity distribution in the cast when using Retronose than nasal spray. The variability of drug deposition in the three nasal cast models was lower when using Retronose than nasal spray pump.