Can a cyclone spacer reduce the flow rate dependence of dry powder inhalation?

I Parisini, SJ Cheng, DD Symons, MB Brown, A Kostrzewski and D Murnane

Dry powder inhalers are used in pulmonary disease therapies. However, lung deposition is affected by the poor inhalation flow rates achieved by patients. The ability of a cyclone spacer to reduce the flow rate dependence of aerosol emission was investigated. The aerosolization of salbutamol sulphate/lactose was studied between 30-60 Lmin-1 using the Cyclohaler, with and without a manufactured in-house Perspex cyclone device. Deposition of particles in the next generation impactor and within the devices was assessed by high performance liquid chromatography. High dose retention in the cyclone was seen: however, this decreased by increasing the flow rate. Fine particle fractions were substantially higher when the cyclone was employed (e.g. 92.2 ± 7.7 % with cyclone vs. 27.9 ± 3.5 % without cyclone at 45 Lmin-1). This work has shown the potential of a cyclone-spacer to mitigate the flow rate-dependency of emitted particle size and improve inhaled drug delivery.

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