Bioengineering Strategies for Targeted Therapeutic Delivery to the Lungs

Sznitman Josué, Dr. Sc.

Department of Biomedical Engineering,Technion, Israel-Institute of Technology

Our research lies at the crossroads of biomedical engineering and respiratory medicine. Driven by a desire to uncover the scientific underpinnings of respiratory phenomena, we leverage such knowledge towards novel strategies for delivering pulmonary therapies, including foremost inhalation aerosols. Our interdisciplinary team bridges expertise spanning bioengineering, nanotechnology and cell physiology. Our methodologies integrate cellular in vitro experiments and in silico simulations to devise biologically relevant lung models, with broad applications to drug delivery as well as cytotoxicity. Given the complexity of the lungs, our strength revolves around a multiscale approach, from the alveolar microscales to macroscopic whole-organ models. We exemplify below some of our leading contributions and ongoing efforts in the field.